Sisomicin (bactoCeaze or Ensamycin) is an aminoglycoside antibiotic, isolated from the fermentation broth of a new species of the genus Micromonospora. It is a newer broad-spectrum aminoglycoside most structurally related to gentamicin.
Sisomicin is the most predictably active aminoglycoside against gram-positive bacteria. Like most other aminoglycosides, Sisomicin is bactericidal for sensitive clinical isolates. The minimum bactericidal concentrations (MBC) have been found to be equivalent or very close to the minimum inhibitory concentrations (MIC). Like other aminoglycosides, most clinical isolates of Pseudomonas aeruginosa remain susceptible to sisomicin. Resistance to sisomicin may be enzymatically or non-enzymatically mediated. Sisomicin is inactivated by the same enzymes as gentamicin but it is active against many, not all, organisms that resist gentamicin by non-enzymatic mechanisms.
Some studies show that sisomicin has been effective in the treatment of infections that either had failed to respond to other drugs or were due to microorganisms resistant in vitro to other aminoglycosides.

Chemical Name	sisomycin
Synonyms	Siseptin;Rickamicin;Dehydrogentamicin Cla;Sisomicin;SISOMYCIN;Antibiotic 6640;Sisomicin (C1a Oxidation Peak);Collapse
CAS No.	32385-11-8
Molecular Formula	C19H39N5O11S
Molecular Weight	545.60500
PSA	296.70000
LogP	-0.23140

Density	1.38g/cm3
Boiling Point	676.6ºC at 760mmHg
Flash Point	363ºC