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  • SU 6656  330161-87-0
Name:SU 6656 330161-87-0
CAS No:330161-87-0

PRODUCT DESCRIPTION

SU 6656

CAS No.: 330161-87-0
Synonyms:
    Formula: C19H21N3O3S
    Exact Mass: 371.13000
    Molecular Weight: 371.45300
    PSA: 90.65000
    LogP: 3.85530
    DescriptionFeedback
    SU6656 is a Src family kinase inhibitor developed by the biotechnology company SUGEN Inc (a subsidiary of Pharmacia) in 2000. SU6656 was initially identified as a Src kinase inhibitor by virtue of its ability to reverse an effect that an activated mutant form of Src (hu SRC Y530F) has on the actin cytoskeleton, namely the formation of podosome rosettes, otherwise known as invadopodia. SU6656 was initially published as a Src family kinase inhibitor with selectivity relative to Platelet-derived growth factor receptor Tyrosine kinase. Subsequent studies have confirmed that SU6656 is relatively selective for Src family kinases but some additional biochemical activities have been identified including: BRSK2, AMPK, Aurora C, Aurora B, CaMKKβ. The inhibition of these kinases in biochemical reactions in vitro does not necessarily indicate that these kinases are targets of SU6656 in cells.
    SU6656 has been used primarily as a research tool to investigate the function of Src family kinases in cellular signal transduction processes and biology.

    PropertiesFeedback
    Density: 1.378g/cm3
    Refractive Index: 1.656

    SAFETY DATA SHEETS

    According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

    Version: 1.0

    Creation Date: Aug 19, 2017

    Revision Date: Aug 19, 2017

    1.Identification

    1.1GHS Product identifier

    Product name SU 6656

    1.2Other means of identification

    Product number -
    Other names -

    1.3Recommended use of the chemical and restrictions on use

    Identified uses For industry use only.
    Uses advised against no data available

    1.4Supplier's details

    Fax

    1.5Emergency phone number

    Emergency phone number
    Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

    2.Hazard identification

    2.1Classification of the substance or mixture

    no data available

    2.2GHS label elements, including precautionary statements

    Pictogram(s) no data available
    Signal word

    no data available

    Hazard statement(s)

    no data available

    Precautionary statement(s)
    Prevention

    no data available

    Response

    no data available

    Storage

    no data available

    Disposal

    no data available

    2.3Other hazards which do not result in classification

    no data available

    3.Composition/information on ingredients

    3.1Substances

    Chemical name Common names and synonyms CAS number EC number Concentration
    SU 6656 SU 6656 330161-87-0 none 100%

    4.First-aid measures

    4.1Description of necessary first-aid measures

    General advice

    Consult a physician. Show this safety data sheet to the doctor in attendance.

    If inhaled

    If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.

    In case of skin contact

    Wash off with soap and plenty of water. Consult a physician.

    In case of eye contact

    Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.

    If swallowed

    Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

    4.2Most important symptoms/effects, acute and delayed

    no data available

    4.3Indication of immediate medical attention and special treatment needed, if necessary

    no data available

    5.Fire-fighting measures

    5.1Extinguishing media

    Suitable extinguishing media

    Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.

    5.2Specific hazards arising from the chemical

    no data available

    5.3Special protective actions for fire-fighters

    Wear self-contained breathing apparatus for firefighting if necessary.

    6.Accidental release measures

    6.1Personal precautions, protective equipment and emergency procedures

    Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8.

    6.2Environmental precautions

    Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided.

    6.3Methods and materials for containment and cleaning up

    Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

    7.Handling and storage

    7.1Precautions for safe handling

    Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2.

    7.2Conditions for safe storage, including any incompatibilities

    Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

    8.Exposure controls/personal protection

    8.1Control parameters

    Occupational Exposure limit values

    no data available

    Biological limit values

    no data available

    8.2Appropriate engineering controls

    Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.

    8.3Individual protection measures, such as personal protective equipment (PPE)

    Eye/face protection

    Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

    Skin protection

    Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.

    Respiratory protection

    Wear dust mask when handling large quantities.

    Thermal hazards

    no data available

    9.Physical and chemical properties

    Physical state no data available
    Colour no data available
    Odour no data available
    Melting point/ freezing point no data available
    Boiling point or initial boiling point and boiling range no data available
    Flammability no data available
    Lower and upper explosion limit / flammability limit no data available
    Flash point no data available
    Auto-ignition temperature no data available
    Decomposition temperature no data available
    pH no data available
    Kinematic viscosity no data available
    Solubility no data available
    Partition coefficient n-octanol/water (log value) no data available
    Vapour pressure no data available
    Density and/or relative density 1.378g/cm3
    Relative vapour density no data available
    Particle characteristics no data available

    10.Stability and reactivity

    10.1Reactivity

    no data available

    10.2Chemical stability

    Stable under recommended storage conditions.

    10.3Possibility of hazardous reactions

    no data available

    10.4Conditions to avoid

    no data available

    10.5Incompatible materials

    no data available

    10.6Hazardous decomposition products

    no data available

    11.Toxicological information

    Acute toxicity

    • Oral: no data available
    • Inhalation: no data available
    • Dermal: no data available

    Skin corrosion/irritation

    no data available

    Serious eye damage/irritation

    no data available

    Respiratory or skin sensitization

    no data available

    Germ cell mutagenicity

    no data available

    Carcinogenicity

    no data available

    Reproductive toxicity

    no data available

    STOT-single exposure

    no data available

    STOT-repeated exposure

    no data available

    Aspiration hazard

    no data available

    12.Ecological information

    12.1Toxicity

    • Toxicity to fish: no data available
    • Toxicity to daphnia and other aquatic invertebrates: no data available
    • Toxicity to algae: no data available
    • Toxicity to microorganisms: no data available

    12.2Persistence and degradability

    no data available

    12.3Bioaccumulative potential

    no data available

    12.4Mobility in soil

    no data available

    12.5Other adverse effects

    no data available

    13.Disposal considerations

    13.1Disposal methods

    Product

    The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.

    Contaminated packaging

    Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.

    14.Transport information

    14.1UN Number

    ADR/RID: Not dangerous goods. IMDG: Not dangerous goods. IATA: Not dangerous goods.

    14.2UN Proper Shipping Name

    ADR/RID: unknown
    IMDG: unknown
    IATA: unknown

    14.3Transport hazard class(es)

    ADR/RID: Not dangerous goods. IMDG: Not dangerous goods. IATA: Not dangerous goods.

    14.4Packing group, if applicable

    ADR/RID: Not dangerous goods. IMDG: Not dangerous goods. IATA: Not dangerous goods.

    14.5Environmental hazards

    ADR/RID: no IMDG: no IATA: no

    14.6Special precautions for user

    no data available

    14.7Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code

    no data available

    15.Regulatory information

    15.1Safety, health and environmental regulations specific for the product in question

    Chemical name Common names and synonyms CAS number EC number
    SU 6656 SU 6656 330161-87-0 none
    European Inventory of Existing Commercial Chemical Substances (EINECS) Not Listed.
    EC Inventory Not Listed.
    United States Toxic Substances Control Act (TSCA) Inventory Not Listed.
    China Catalog of Hazardous chemicals 2015 Not Listed.
    New Zealand Inventory of Chemicals (NZIoC) Not Listed.
    Philippines Inventory of Chemicals and Chemical Substances (PICCS) Not Listed.
    Vietnam National Chemical Inventory Not Listed.
    Chinese Chemical Inventory of Existing Chemical Substances (China IECSC) Not Listed.

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