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  • Tetracaine hydrochloride  136-47-0
Name:Tetracaine hydrochloride 136-47-0
CAS No:136-47-0



Tetracaine (also known as amethocaine) is a local anesthetic of the ester anesthetic group. It is mainly used topically in ophthalmology and as an antipruritic, and it has been used in spinal anesthesia.
In biomedical research, tetracaine is used to alter the function of calcium release channels (ryanodine receptors) that control the release of calcium from intracellular stores. Tetracaine is an allosteric blocker of channel function. At low concentrations, tetracaine causes an initial inhibition of spontaneous calcium release events, while at high concentrations, tetracaine blocks release completely.
Tetracaine is the T in TAC, a mixture of 5 to 12 per cent tetracaine, 0.05 per cent adrenaline, and 4 or 10 per cent cocaine hydrochloride used in ear, nose & throat surgery and in the emergency department where numbing of the surface is needed rapidly, especially when children have been injured in the eye, ear, or other sensitive locations.
It is on the World Health Organization's List of Essential Medicines, a list of the most important medication needed in a basic health system.
A systematic review investigated tetracaine for use in emergency departments, especially for IV cannulation in children, in view of its analgesic and cost-saving properties. However, it did not find an improvement in first attempt cannulations.

Basic Info

Chemical Name Tetracaine hydrochloride

tonexol;Benzoic acid, 4-(butylamino)-, 2-(dimethylamino)ethyl ester, monohydrochloride;PANTOCAINE;4-(Butylamino)benzoic acid 2-(dimethylamino)ethyl ester,Amethocaine hydrochloride;anethaine;Tetracaine (hydrochloride);menonasal;decicaine;4-(Butylamino)benzoic acid 2-(dimethylamino)ethyl ester,Ameth;butethanol;decicain;gingicainm;Tetracaine HCl;curtacain;anacel;Collapse

CAS No. 136-47-0
Molecular Formula C15H25ClN2O2
Molecular Weight 300.82400
PSA 41.57000
LogP 3.49200


Appearance & Physical State White or off white crystalline powder
Boiling Point 389.4ºC at 760 mmHg
Melting Point 149ºC
Flash Point 189.3ºC
Stability Stable at normal temperatures and pressures.
Storage Condition Keep tightly closed.
Vapor Pressure 2.87E-06mmHg at 25°C

Safety Info

RTECS DG4900000
Hazard Class 6.1
Safety Statements S26-S36/37-S45
HS Code 2942000000
Packing Group III
Risk Statements R25; R36; R43
Hazard Codes T