FRIDAY, Nov. 18, 2022 -- A risk score tool can accurately predict an individual’s 13-year dementia risk, according to a study published online Nov. 17 in JAMA Network Open.
Lina Ren, from Shenzhen Mental Health Centre in China, and colleagues developed a point risk score prediction model for dementia using data from a diagnostic study of 444,695 U.K. individuals.
The researchers found that dementia occurrence during the 13 years of follow-up (mean age at baseline, 56.2 years) was 0.7 percent for men and 0.5 percent for women. In the training set, the C statistic of the final multivariate Cox proportional hazards regression model was 0.86 for men and 0.85 for women versus 0.85 for men and 0.87 for women in the testing data set. Some modifiable risk and protective factors were similar between men and women, but they also presented independent risk factors that accounted for 31.7 percent of men developing dementia and 53.35 percent of women developing dementia, according to the weighted population-attributable fraction. The total point score of the risk score model ranged from −18 to 30 in men versus −17 to 30 in women. For both genders, the risk score model yielded nearly 100 percent prediction accuracy of 13-year dementia risk.
"The findings of this diagnostic study suggest that a risk score tool can be used for individual prediction of dementia risk that may help individuals to identify their potential risk profile and provide guidance on precise and timely actions to take to prevent or delay dementia," the authors write.
![(3S)-3-[4-[7-[[(1,1-Dimethylethyl)amino]carbonyl]-2H-indazol-2-yl]phenyl]-1-piperidinecarboxylic acid 1,1-dimethylethyl ester](/data/attachment/201705/26/3446bd2b841689a5afc36447418dc476.png "(3S)-3-[4-[7-[[(1,1-Dimethylethyl)amino]carbonyl]-2H-indazol-2-yl]phenyl]-1-piperidinecarboxylic acid 1,1-dimethylethyl ester")
![N-(1,1-Dimethylethyl)-2-[4-(3S)-3-piperidinylphenyl]-2H-indazole-7-carboxamide](/data/attachment/201705/26/da41ae70b523a458db70333bd1059362.png "N-(1,1-Dimethylethyl)-2-[4-(3S)-3-piperidinylphenyl]-2H-indazole-7-carboxamide")
![2-{4-[(3S)-piperidin-3-yl]phenyl}-2H-indazole-7-carboxamide](/data/attachment/201705/26/d3114dd994f3dda3142cba7d326bcede.jpg "2-{4-[(3S)-piperidin-3-yl]phenyl}-2H-indazole-7-carboxamide")
![9-ethyl-8-iodo-6,6-diMethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile](/data/attachment/201705/28/e48e5d316800efe6192ebfdeec6cf28c.gif "9-ethyl-8-iodo-6,6-diMethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile")
![9-broMo-8-hydroxy-6,6-diMethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile](/data/attachment/201705/28/fe98529212eb834b17a38f13138a35bf.png "9-broMo-8-hydroxy-6,6-diMethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile")
![9-ethyl-6,6-diMethyl-8-(4-Morpholinopiperidin-1-yl)-11-oxo-5a,6,11,11a-tetrahydro-5H-benzo[b]carbazole-3-carbonitrile hydrochloride](/data/attachment/201705/28/36e5363f0c9f92378b75195743e2abb2.jpg "9-ethyl-6,6-diMethyl-8-(4-Morpholinopiperidin-1-yl)-11-oxo-5a,6,11,11a-tetrahydro-5H-benzo[b]carbazole-3-carbonitrile hydrochloride")
![2-Methylpyrazolo[1,5-a]pyrimidine-6-carboxamide](/data/attachment/201706/03/2e19d959128718d26901f9909d7b9342.jpg "2-Methylpyrazolo[1,5-a]pyrimidine-6-carboxamide")
![11-(1-Methylpiperidin-4-ylidene)-6,11-dihydro-5H-benzo[d]iMidazo[1,2-a]azepine](/data/attachment/201706/03/1549d9affee63ead337049001f25d9fa.jpg "11-(1-Methylpiperidin-4-ylidene)-6,11-dihydro-5H-benzo[d]iMidazo[1,2-a]azepine")
![tert-butyl 5-tosyl-5H-pyrrolo[2,3-b]pyrazin-2-ylcarbamate](/data/attachment/201706/03/8a3c0fcdeb9ed744fc854cf248d4d53e.jpg "tert-butyl 5-tosyl-5H-pyrrolo[2,3-b]pyrazin-2-ylcarbamate")
![2-Furanpropanol, 5-[2-[(2S,4R,6R)-6-[[(2S,3S,4R,5R)-5-[(2S)-2,3-bis[[(1,1-dimethylethyl)dimethylsilyl]oxy]propyl]tetrahydro-4-methoxy-3-[(phenylsulfonyl) methyl]-2-furanyl]methyl]tetrahydro-4-methyl-5-methylene-2H-pyran-2-yl]ethyl]tetrahydro-4-methylene-,](/data/attachment/201706/03/3575f40dcc389832ca73cc99972a645b.gif.thumb.jpg "2-Furanpropanol, 5-[2-[(2S,4R,6R)-6-[[(2S,3S,4R,5R)-5-[(2S)-2,3-bis[[(1,1-dimethylethyl)dimethylsilyl]oxy]propyl]tetrahydro-4-methoxy-3-[(phenylsulfonyl) methyl]-2-furanyl]methyl]tetrahydro-4-methyl-5-methylene-2H-pyran-2-yl]ethyl]tetrahydro-4-methylene-,")
![6-[(6-Bromo-1H-[1,2,3]triazolo[4,5-b]pyrazin-1-yl)methyl]-7-fluoroquinoline](/data/attachment/201706/07/27ae4307b53f4294590fb8f914894490.jpg "6-[(6-Bromo-1H-[1,2,3]triazolo[4,5-b]pyrazin-1-yl)methyl]-7-fluoroquinoline")
![7-Trifluoromethyl-imidazo[1,2-a]pyridine](/data/attachment/201706/07/24ba6100528abe0753ad9e82ef8dc810.gif "7-Trifluoromethyl-imidazo[1,2-a]pyridine")
![2-AMino-4,5,6,7-tetrahydro-benzo[b]thiophene-3-carboxylic acid tert-butyl ester](/data/attachment/201706/07/22aadd4c55094254a681014935f56827.jpg "2-AMino-4,5,6,7-tetrahydro-benzo[b]thiophene-3-carboxylic acid tert-butyl ester")
![Benzenemethanol, a-[(1S)-1-aminoethyl]-4-hydroxy-,(aR)](/data/attachment/201706/07/c4adcbada0ef372ae46cbaed643dd18e.jpg "Benzenemethanol, a-[(1S)-1-aminoethyl]-4-hydroxy-,(aR)")
![2(1H)-Quinolinone,5-[(1R)-2-amino-1-[[(1,1-dimethylethyl)dimethylsilyl]oxy]ethyl]-8-hydroxy](/data/attachment/201706/07/e0e9b5769a45af836d70be4140043125.gif.thumb.jpg "2(1H)-Quinolinone,5-[(1R)-2-amino-1-[[(1,1-dimethylethyl)dimethylsilyl]oxy]ethyl]-8-hydroxy")
![2-{[3-(4-Fluorophenyl)-4-oxo-3,4,6,7-tetrahydrothieno[3,2-d]pyrim idin-2-yl]sulfanyl}-N-(6-methyl-1,3-benzothiazol-2-yl)acetamide](/data/attachment/201706/07/5754ee36bdfbf4148f45632422f563b9.jpg "2-{[3-(4-Fluorophenyl)-4-oxo-3,4,6,7-tetrahydrothieno[3,2-d]pyrim idin-2-yl]sulfanyl}-N-(6-methyl-1,3-benzothiazol-2-yl)acetamide")
![2-((3-(2-methoxyphenyl)-4-oxo-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)-N-(6-methylbenzo[d]thiazol-2-yl)acetamide](/data/attachment/201706/08/47a8b3c98aef0b9ba378c4b7c6cef435.jpg "2-((3-(2-methoxyphenyl)-4-oxo-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)-N-(6-methylbenzo[d]thiazol-2-yl)acetamide")
![N-(6-Methyl-2-benzothiazolyl)-2-[(3,4,6,7-tetrahydro-4-oxo-3-phenylthieno[3,2-d]pyrimidin-2-yl)thio]-acetamide](/data/attachment/201706/08/beda6f8f4655aa74d3646cfc7621fb20.jpg "N-(6-Methyl-2-benzothiazolyl)-2-[(3,4,6,7-tetrahydro-4-oxo-3-phenylthieno[3,2-d]pyrimidin-2-yl)thio]-acetamide")
![4(3H)-Quinazolinone,7-bromo-6-chloro-3-[3-(3-hydroxy-2-piperidinyl)-2-oxopropyl]](/data/attachment/201706/09/b600ffca12695094db2c5f6045cb6685.jpg "4(3H)-Quinazolinone,7-bromo-6-chloro-3-[3-(3-hydroxy-2-piperidinyl)-2-oxopropyl]")
![9-OXO-1,2,3,9-TETRAHYDRO-PYRROLO[2,1-B]QUINAZOLINE-6-CARBOXYLIC ACID](/data/attachment/201706/09/d6b395bbfb23e628be7d536d9cc2b512.gif "9-OXO-1,2,3,9-TETRAHYDRO-PYRROLO[2,1-B]QUINAZOLINE-6-CARBOXYLIC ACID")
![2-Butenoic acid, 2-hydroxy-4-[5-(1-Methylethyl)-2,4-bis(phenylMethoxy)phenyl]-4-oxo-, ethyl ester](/data/attachment/201706/09/11c6e17ba89840528c5461ae5350df33.gif "2-Butenoic acid, 2-hydroxy-4-[5-(1-Methylethyl)-2,4-bis(phenylMethoxy)phenyl]-4-oxo-, ethyl ester")
methanone](/data/attachment/201706/09/ca947be16560699c92609cd96b352c02.png.thumb.jpg "[4-amino-2-(ethylsulfanyl)pyrimidin-5-yl](2,3-difluoro-6-methoxyphenyl)methanone")
![Benzenesulfonamide, 2-[(5-bromo-2-chloro-4-pyrimidinyl)amino]-N-methyl](/data/attachment/201706/10/ce0d621896c03bdb67e3b184103e84ff.png.thumb.jpg "Benzenesulfonamide, 2-[(5-bromo-2-chloro-4-pyrimidinyl)amino]-N-methyl")
![1,2,3,4-Tetrahydro-benzo[b]azepin-5-one 1127-74-8](/data/attachment/201901/28/b183df1e648eca4396ad0d319a1254bc.jpg "1,2,3,4-Tetrahydro-benzo[b]azepin-5-one 1127-74-8")
1127-74-8,1,2,3,4-Tetrahydro-benzo[b]azepin-5-one
Read More
4038-14-6,(3,4-dimethoxyphenyl)-phenylmethanone
Read More
![3-Ethynylimidazo[1,2-a]pyridine 943320-53-4](/data/attachment/201901/28/d6294d1dabcee85ee04792b0c0e255c0.jpg "3-Ethynylimidazo[1,2-a]pyridine 943320-53-4")
![2-[3-(trifluoromethyl)phenyl]acetonitrile 2338-76-3](/data/attachment/201901/29/22b99245cb0bbcd2d86f238725d9fb9d.jpg "2-[3-(trifluoromethyl)phenyl]acetonitrile 2338-76-3")
2338-76-3,2-[3-(trifluoromethyl)phenyl]acetonitrile
Read More![2-[3-(trifluoromethyl)phenyl]acetic acid 351-35-9](/data/attachment/201901/29/7dbc74a276a4c124b9460222442fd80f.jpg "2-[3-(trifluoromethyl)phenyl]acetic acid 351-35-9")
351-35-9,2-[3-(trifluoromethyl)phenyl]acetic acid
Read More
2997-92-4,2,2'-Azobis(2-methylpropionamidine) dihydrochloride
Read More
95585-78-7,L-Phenylalanine, 1-methylethyl ester, hydrochloride
Read More
20324-87-2,Disodium 7,7'-(carbonyldiimino)bis(4-hydroxynaphthalene-2-sulphonate)
Read More
182498-32-4,1-(2-bromophenyl)-3-(2-hydroxy-4-nitrophenyl)urea
Read More
![(4-nitrophenyl) 4-[bis(1,3-benzodioxol-5-yl)-hydroxymethyl]piperidine-1-carboxylate 1101854-58-3](/data/attachment/201903/22/9e81dae7e0bdec56ac6052b1872d9626.jpg "(4-nitrophenyl) 4-[bis(1,3-benzodioxol-5-yl)-hydroxymethyl]piperidine-1-carboxylate 1101854-58-3")
1101854-58-3,(4-nitrophenyl) 4-[bis(1,3-benzodioxol-5-yl)-hydroxymethyl]piperidine-1-carboxylate
Read More
170565-89-6,N,N-dimethyl-2-oxo-1,3-dihydroindole-5-sulfonamide
Read More![5,6,11,12-tetrahydrodibenzo[1,2-b:1,2-g][8]annulene 1460-59-9](/data/attachment/201903/23/50930df6d55412ac8f4da0724b497aaf.jpg "5,6,11,12-tetrahydrodibenzo[1,2-b:1,2-g][8]annulene 1460-59-9")
1460-59-9,5,6,11,12-tetrahydrodibenzo[1,2-b:1',2'-g][8]annulene
Read More
![2-chloro-6-[(2R)-2-hydroxy-3-[(2-methyl-1-naphthalen-2-ylpropan-2-yl)amino]propoxy]benzonitrile 284035-33-2](/data/attachment/201903/23/7e63bafe6c4b7e146e00c57dfca99672.jpg "2-chloro-6-[(2R)-2-hydroxy-3-[(2-methyl-1-naphthalen-2-ylpropan-2-yl)amino]propoxy]benzonitrile 284035-33-2")
284035-33-2,2-chloro-6-[(2R)-2-hydroxy-3-[(2-methyl-1-naphthalen-2-ylpropan-2-yl)amino]propoxy]benzonitrile
Read More
![N-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methyl-1-oxo-1,2-dihydroisoquinoline-4-carboxamide 440662-09-9](/data/attachment/201903/23/e26baac537719657acd9f1f55568401d.jpg "N-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methyl-1-oxo-1,2-dihydroisoquinoline-4-carboxamide 440662-09-9")
440662-09-9,N-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methyl-1-oxo-1,2-dihydroisoquinoline-4-carboxamide
Read More![N-[2-[2-(4-chlorophenyl)-1,3-thiazol-4-yl]ethyl]butanamide 932986-18-0](/data/attachment/201903/23/7d2bbd100c8322ae16168937617e1bb2.jpg "N-[2-[2-(4-chlorophenyl)-1,3-thiazol-4-yl]ethyl]butanamide 932986-18-0")
932986-18-0,N-[2-[2-(4-chlorophenyl)-1,3-thiazol-4-yl]ethyl]butanamide
Read More
1234015-52-1,5-(5-(2-(3-aminopropoxy)-6-methoxyphenyl)-1H-pyrazol-3-ylamino)pyrazine-2-carbonitrile
Read More![3-Methyl-3-[(1E)-2-phenylethenyl]-3,2:5,2:5,3-quaterpyridine 1651890-44-6](/data/attachment/201903/23/07bf6fd99e81033df0c83039ccdde036.jpg "3-Methyl-3-[(1E)-2-phenylethenyl]-3,2:5,2:5,3-quaterpyridine 1651890-44-6")
1651890-44-6,3'-Methyl-3''-[(1E)-2-phenylethenyl]-3,2':5',2'':5'',3'''-quaterpyridine
Read More![3-[4-(Dimethylamino)-3-biphenylyl]-1,1-dimethylure 1469924-27-3](/data/attachment/201903/23/f69ad7342d131146640e0c88f73e9a25.jpg "3-[4-(Dimethylamino)-3-biphenylyl]-1,1-dimethylure 1469924-27-3")
1469924-27-3,3-[4'-(Dimethylamino)-3-biphenylyl]-1,1-dimethylure
Read More
3897-94-7,8-Methoxy-N,N-dipropyl-1,2,3,4-tetrahydro-2-naphthalenamine
Read More![4-{4-[(4-{[3-(Acryloylamino)phenyl]amino}-5-fluoro-2-pyrimidinyl) amino]phenoxy}-N-methyl-2-pyridinecarboxamide 1202759-32-7](/data/attachment/201903/23/bb4110673d0676f81860d708092eb660.jpg "4-{4-[(4-{[3-(Acryloylamino)phenyl]amino}-5-fluoro-2-pyrimidinyl) amino]phenoxy}-N-methyl-2-pyridinecarboxamide 1202759-32-7")
1202759-32-7,4-{4-[(4-{[3-(Acryloylamino)phenyl]amino}-5-fluoro-2-pyrimidinyl) amino]phenoxy}-N-methyl-2-pyridinecarboxamide
Read More
71145-03-4,1,4-Dihydro-2,6-dimethyl-3-nitro-4-(2-trifluoromethylphenyl)-pyridine-5-carboxylic acid methyl ester
Read More![2-[[3-[[2-(dimethylamino)phenyl]methyl]-2-pyridin-4-yl-1,3-diazinan-1-yl]methyl]-N,N-dimethylaniline 500579-04-4](/data/attachment/201903/23/b396a2326dddb511aae497b01fbd4c77.jpg "2-[[3-[[2-(dimethylamino)phenyl]methyl]-2-pyridin-4-yl-1,3-diazinan-1-yl]methyl]-N,N-dimethylaniline 500579-04-4")
500579-04-4,2-[[3-[[2-(dimethylamino)phenyl]methyl]-2-pyridin-4-yl-1,3-diazinan-1-yl]methyl]-N,N-dimethylaniline
Read More
1443437-74-8,N-(4-chlorophenyl)-1-(3-(furan-2-yl)benzoyl)piperidine-3-carboxamide
Read More
1125-29-7 1,3,5-Trimethyl-1H-pyrazole-4-carboxylic acid
Read More
![[2-(aminocarbonyl)phenyl]acetic acid 23362-56-3](/data/attachment/202211/10/9756043560e11c17cf958f3ed54d541a.png.thumb.jpg "[2-(aminocarbonyl)phenyl]acetic acid 23362-56-3")
23362-56-3 [2-(aminocarbonyl)phenyl]acetic acid
Read More
103788-65-4 2-(5-Methyl-2-phenyl-1,3-oxazol-4-yl)ethan-1-ol
Read More
120503-69-7 2-Amino-6-cyclopropylamino-9H-purine
Read More
Deutsche
Español
français
italiano
português
日本語
한국어
العربية
русский
bahasa Indonesia
Tiếng Việt
Send Email
Skype
3391543003
+86 15195055733
