TUESDAY, Nov. 9, 2021 -- Patients with migraine without prior clinical care have reduced gray matter volume (GMV) in the right dorsal medial prefrontal cortex (dMPFC) compared to those with prior care, according to a study published online Oct. 23 in The Journal of Headache and Pain.
Shana A.B. Burrowes, Ph.D., from the Boston University School of Medicine, and colleagues examined differences in GMV for migraine patients with and without prior clinical care for migraine, as determined by diagnosis by a medical practitioner or prescription of migraine-specific medication. Baseline magnetic resonance imaging and psychosocial symptom questionnaires were used from a longitudinal randomized controlled trial. Data were included for 117 patients: 23 without prior care and 94 with prior medical care, and for 36 healthy controls.
The researchers found that relative to patients who had prior care, patients without prior care had reduced GMV in the right dMPFC. Compared with healthy controls, both patient groups had reduced GMV. There was no difference observed between the patient groups for headache clinical variables. Increasing scores on stress and depression questionnaires (Perceived Stress Score and Patient Health Questionnaire) were associated with increased GMV in the dMPFC, regardless of medical care status.
"Our results provide further evidence that episodic migraine patients who are not receiving care may have an added burden associated with this lack of care even though clinically they may present the same," the authors write. "Given these findings it is clear that efforts to improve access to migraine treatment need to be expanded."
![(3S)-3-[4-[7-[[(1,1-Dimethylethyl)amino]carbonyl]-2H-indazol-2-yl]phenyl]-1-piperidinecarboxylic acid 1,1-dimethylethyl ester](/data/attachment/201705/26/3446bd2b841689a5afc36447418dc476.png "(3S)-3-[4-[7-[[(1,1-Dimethylethyl)amino]carbonyl]-2H-indazol-2-yl]phenyl]-1-piperidinecarboxylic acid 1,1-dimethylethyl ester")
![N-(1,1-Dimethylethyl)-2-[4-(3S)-3-piperidinylphenyl]-2H-indazole-7-carboxamide](/data/attachment/201705/26/da41ae70b523a458db70333bd1059362.png "N-(1,1-Dimethylethyl)-2-[4-(3S)-3-piperidinylphenyl]-2H-indazole-7-carboxamide")
![2-{4-[(3S)-piperidin-3-yl]phenyl}-2H-indazole-7-carboxamide](/data/attachment/201705/26/d3114dd994f3dda3142cba7d326bcede.jpg "2-{4-[(3S)-piperidin-3-yl]phenyl}-2H-indazole-7-carboxamide")
![9-ethyl-8-iodo-6,6-diMethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile](/data/attachment/201705/28/e48e5d316800efe6192ebfdeec6cf28c.gif "9-ethyl-8-iodo-6,6-diMethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile")
![9-broMo-8-hydroxy-6,6-diMethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile](/data/attachment/201705/28/fe98529212eb834b17a38f13138a35bf.png "9-broMo-8-hydroxy-6,6-diMethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile")
![9-ethyl-6,6-diMethyl-8-(4-Morpholinopiperidin-1-yl)-11-oxo-5a,6,11,11a-tetrahydro-5H-benzo[b]carbazole-3-carbonitrile hydrochloride](/data/attachment/201705/28/36e5363f0c9f92378b75195743e2abb2.jpg "9-ethyl-6,6-diMethyl-8-(4-Morpholinopiperidin-1-yl)-11-oxo-5a,6,11,11a-tetrahydro-5H-benzo[b]carbazole-3-carbonitrile hydrochloride")
![2-Methylpyrazolo[1,5-a]pyrimidine-6-carboxamide](/data/attachment/201706/03/2e19d959128718d26901f9909d7b9342.jpg "2-Methylpyrazolo[1,5-a]pyrimidine-6-carboxamide")
![11-(1-Methylpiperidin-4-ylidene)-6,11-dihydro-5H-benzo[d]iMidazo[1,2-a]azepine](/data/attachment/201706/03/1549d9affee63ead337049001f25d9fa.jpg "11-(1-Methylpiperidin-4-ylidene)-6,11-dihydro-5H-benzo[d]iMidazo[1,2-a]azepine")
![tert-butyl 5-tosyl-5H-pyrrolo[2,3-b]pyrazin-2-ylcarbamate](/data/attachment/201706/03/8a3c0fcdeb9ed744fc854cf248d4d53e.jpg "tert-butyl 5-tosyl-5H-pyrrolo[2,3-b]pyrazin-2-ylcarbamate")
![2-Furanpropanol, 5-[2-[(2S,4R,6R)-6-[[(2S,3S,4R,5R)-5-[(2S)-2,3-bis[[(1,1-dimethylethyl)dimethylsilyl]oxy]propyl]tetrahydro-4-methoxy-3-[(phenylsulfonyl) methyl]-2-furanyl]methyl]tetrahydro-4-methyl-5-methylene-2H-pyran-2-yl]ethyl]tetrahydro-4-methylene-,](/data/attachment/201706/03/3575f40dcc389832ca73cc99972a645b.gif.thumb.jpg "2-Furanpropanol, 5-[2-[(2S,4R,6R)-6-[[(2S,3S,4R,5R)-5-[(2S)-2,3-bis[[(1,1-dimethylethyl)dimethylsilyl]oxy]propyl]tetrahydro-4-methoxy-3-[(phenylsulfonyl) methyl]-2-furanyl]methyl]tetrahydro-4-methyl-5-methylene-2H-pyran-2-yl]ethyl]tetrahydro-4-methylene-,")
![6-[(6-Bromo-1H-[1,2,3]triazolo[4,5-b]pyrazin-1-yl)methyl]-7-fluoroquinoline](/data/attachment/201706/07/27ae4307b53f4294590fb8f914894490.jpg "6-[(6-Bromo-1H-[1,2,3]triazolo[4,5-b]pyrazin-1-yl)methyl]-7-fluoroquinoline")
![7-Trifluoromethyl-imidazo[1,2-a]pyridine](/data/attachment/201706/07/24ba6100528abe0753ad9e82ef8dc810.gif "7-Trifluoromethyl-imidazo[1,2-a]pyridine")
![2-AMino-4,5,6,7-tetrahydro-benzo[b]thiophene-3-carboxylic acid tert-butyl ester](/data/attachment/201706/07/22aadd4c55094254a681014935f56827.jpg "2-AMino-4,5,6,7-tetrahydro-benzo[b]thiophene-3-carboxylic acid tert-butyl ester")
![Benzenemethanol, a-[(1S)-1-aminoethyl]-4-hydroxy-,(aR)](/data/attachment/201706/07/c4adcbada0ef372ae46cbaed643dd18e.jpg "Benzenemethanol, a-[(1S)-1-aminoethyl]-4-hydroxy-,(aR)")
![2(1H)-Quinolinone,5-[(1R)-2-amino-1-[[(1,1-dimethylethyl)dimethylsilyl]oxy]ethyl]-8-hydroxy](/data/attachment/201706/07/e0e9b5769a45af836d70be4140043125.gif.thumb.jpg "2(1H)-Quinolinone,5-[(1R)-2-amino-1-[[(1,1-dimethylethyl)dimethylsilyl]oxy]ethyl]-8-hydroxy")
![2-{[3-(4-Fluorophenyl)-4-oxo-3,4,6,7-tetrahydrothieno[3,2-d]pyrim idin-2-yl]sulfanyl}-N-(6-methyl-1,3-benzothiazol-2-yl)acetamide](/data/attachment/201706/07/5754ee36bdfbf4148f45632422f563b9.jpg "2-{[3-(4-Fluorophenyl)-4-oxo-3,4,6,7-tetrahydrothieno[3,2-d]pyrim idin-2-yl]sulfanyl}-N-(6-methyl-1,3-benzothiazol-2-yl)acetamide")
![2-((3-(2-methoxyphenyl)-4-oxo-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)-N-(6-methylbenzo[d]thiazol-2-yl)acetamide](/data/attachment/201706/08/47a8b3c98aef0b9ba378c4b7c6cef435.jpg "2-((3-(2-methoxyphenyl)-4-oxo-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)-N-(6-methylbenzo[d]thiazol-2-yl)acetamide")
![N-(6-Methyl-2-benzothiazolyl)-2-[(3,4,6,7-tetrahydro-4-oxo-3-phenylthieno[3,2-d]pyrimidin-2-yl)thio]-acetamide](/data/attachment/201706/08/beda6f8f4655aa74d3646cfc7621fb20.jpg "N-(6-Methyl-2-benzothiazolyl)-2-[(3,4,6,7-tetrahydro-4-oxo-3-phenylthieno[3,2-d]pyrimidin-2-yl)thio]-acetamide")
![4(3H)-Quinazolinone,7-bromo-6-chloro-3-[3-(3-hydroxy-2-piperidinyl)-2-oxopropyl]](/data/attachment/201706/09/b600ffca12695094db2c5f6045cb6685.jpg "4(3H)-Quinazolinone,7-bromo-6-chloro-3-[3-(3-hydroxy-2-piperidinyl)-2-oxopropyl]")
![9-OXO-1,2,3,9-TETRAHYDRO-PYRROLO[2,1-B]QUINAZOLINE-6-CARBOXYLIC ACID](/data/attachment/201706/09/d6b395bbfb23e628be7d536d9cc2b512.gif "9-OXO-1,2,3,9-TETRAHYDRO-PYRROLO[2,1-B]QUINAZOLINE-6-CARBOXYLIC ACID")
![2-Butenoic acid, 2-hydroxy-4-[5-(1-Methylethyl)-2,4-bis(phenylMethoxy)phenyl]-4-oxo-, ethyl ester](/data/attachment/201706/09/11c6e17ba89840528c5461ae5350df33.gif "2-Butenoic acid, 2-hydroxy-4-[5-(1-Methylethyl)-2,4-bis(phenylMethoxy)phenyl]-4-oxo-, ethyl ester")
methanone](/data/attachment/201706/09/ca947be16560699c92609cd96b352c02.png.thumb.jpg "[4-amino-2-(ethylsulfanyl)pyrimidin-5-yl](2,3-difluoro-6-methoxyphenyl)methanone")
![Benzenesulfonamide, 2-[(5-bromo-2-chloro-4-pyrimidinyl)amino]-N-methyl](/data/attachment/201706/10/ce0d621896c03bdb67e3b184103e84ff.png.thumb.jpg "Benzenesulfonamide, 2-[(5-bromo-2-chloro-4-pyrimidinyl)amino]-N-methyl")
![1,2,3,4-Tetrahydro-benzo[b]azepin-5-one 1127-74-8](/data/attachment/201901/28/b183df1e648eca4396ad0d319a1254bc.jpg "1,2,3,4-Tetrahydro-benzo[b]azepin-5-one 1127-74-8")
1127-74-8,1,2,3,4-Tetrahydro-benzo[b]azepin-5-one
Read More
4038-14-6,(3,4-dimethoxyphenyl)-phenylmethanone
Read More
![3-Ethynylimidazo[1,2-a]pyridine 943320-53-4](/data/attachment/201901/28/d6294d1dabcee85ee04792b0c0e255c0.jpg "3-Ethynylimidazo[1,2-a]pyridine 943320-53-4")
![2-[3-(trifluoromethyl)phenyl]acetonitrile 2338-76-3](/data/attachment/201901/29/22b99245cb0bbcd2d86f238725d9fb9d.jpg "2-[3-(trifluoromethyl)phenyl]acetonitrile 2338-76-3")
2338-76-3,2-[3-(trifluoromethyl)phenyl]acetonitrile
Read More![2-[3-(trifluoromethyl)phenyl]acetic acid 351-35-9](/data/attachment/201901/29/7dbc74a276a4c124b9460222442fd80f.jpg "2-[3-(trifluoromethyl)phenyl]acetic acid 351-35-9")
351-35-9,2-[3-(trifluoromethyl)phenyl]acetic acid
Read More
2997-92-4,2,2'-Azobis(2-methylpropionamidine) dihydrochloride
Read More
95585-78-7,L-Phenylalanine, 1-methylethyl ester, hydrochloride
Read More
20324-87-2,Disodium 7,7'-(carbonyldiimino)bis(4-hydroxynaphthalene-2-sulphonate)
Read More
182498-32-4,1-(2-bromophenyl)-3-(2-hydroxy-4-nitrophenyl)urea
Read More
![(4-nitrophenyl) 4-[bis(1,3-benzodioxol-5-yl)-hydroxymethyl]piperidine-1-carboxylate 1101854-58-3](/data/attachment/201903/22/9e81dae7e0bdec56ac6052b1872d9626.jpg "(4-nitrophenyl) 4-[bis(1,3-benzodioxol-5-yl)-hydroxymethyl]piperidine-1-carboxylate 1101854-58-3")
1101854-58-3,(4-nitrophenyl) 4-[bis(1,3-benzodioxol-5-yl)-hydroxymethyl]piperidine-1-carboxylate
Read More
170565-89-6,N,N-dimethyl-2-oxo-1,3-dihydroindole-5-sulfonamide
Read More![5,6,11,12-tetrahydrodibenzo[1,2-b:1,2-g][8]annulene 1460-59-9](/data/attachment/201903/23/50930df6d55412ac8f4da0724b497aaf.jpg "5,6,11,12-tetrahydrodibenzo[1,2-b:1,2-g][8]annulene 1460-59-9")
1460-59-9,5,6,11,12-tetrahydrodibenzo[1,2-b:1',2'-g][8]annulene
Read More
![2-chloro-6-[(2R)-2-hydroxy-3-[(2-methyl-1-naphthalen-2-ylpropan-2-yl)amino]propoxy]benzonitrile 284035-33-2](/data/attachment/201903/23/7e63bafe6c4b7e146e00c57dfca99672.jpg "2-chloro-6-[(2R)-2-hydroxy-3-[(2-methyl-1-naphthalen-2-ylpropan-2-yl)amino]propoxy]benzonitrile 284035-33-2")
284035-33-2,2-chloro-6-[(2R)-2-hydroxy-3-[(2-methyl-1-naphthalen-2-ylpropan-2-yl)amino]propoxy]benzonitrile
Read More
![N-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methyl-1-oxo-1,2-dihydroisoquinoline-4-carboxamide 440662-09-9](/data/attachment/201903/23/e26baac537719657acd9f1f55568401d.jpg "N-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methyl-1-oxo-1,2-dihydroisoquinoline-4-carboxamide 440662-09-9")
440662-09-9,N-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methyl-1-oxo-1,2-dihydroisoquinoline-4-carboxamide
Read More![N-[2-[2-(4-chlorophenyl)-1,3-thiazol-4-yl]ethyl]butanamide 932986-18-0](/data/attachment/201903/23/7d2bbd100c8322ae16168937617e1bb2.jpg "N-[2-[2-(4-chlorophenyl)-1,3-thiazol-4-yl]ethyl]butanamide 932986-18-0")
932986-18-0,N-[2-[2-(4-chlorophenyl)-1,3-thiazol-4-yl]ethyl]butanamide
Read More
1234015-52-1,5-(5-(2-(3-aminopropoxy)-6-methoxyphenyl)-1H-pyrazol-3-ylamino)pyrazine-2-carbonitrile
Read More![3-Methyl-3-[(1E)-2-phenylethenyl]-3,2:5,2:5,3-quaterpyridine 1651890-44-6](/data/attachment/201903/23/07bf6fd99e81033df0c83039ccdde036.jpg "3-Methyl-3-[(1E)-2-phenylethenyl]-3,2:5,2:5,3-quaterpyridine 1651890-44-6")
1651890-44-6,3'-Methyl-3''-[(1E)-2-phenylethenyl]-3,2':5',2'':5'',3'''-quaterpyridine
Read More![3-[4-(Dimethylamino)-3-biphenylyl]-1,1-dimethylure 1469924-27-3](/data/attachment/201903/23/f69ad7342d131146640e0c88f73e9a25.jpg "3-[4-(Dimethylamino)-3-biphenylyl]-1,1-dimethylure 1469924-27-3")
1469924-27-3,3-[4'-(Dimethylamino)-3-biphenylyl]-1,1-dimethylure
Read More
3897-94-7,8-Methoxy-N,N-dipropyl-1,2,3,4-tetrahydro-2-naphthalenamine
Read More![4-{4-[(4-{[3-(Acryloylamino)phenyl]amino}-5-fluoro-2-pyrimidinyl) amino]phenoxy}-N-methyl-2-pyridinecarboxamide 1202759-32-7](/data/attachment/201903/23/bb4110673d0676f81860d708092eb660.jpg "4-{4-[(4-{[3-(Acryloylamino)phenyl]amino}-5-fluoro-2-pyrimidinyl) amino]phenoxy}-N-methyl-2-pyridinecarboxamide 1202759-32-7")
1202759-32-7,4-{4-[(4-{[3-(Acryloylamino)phenyl]amino}-5-fluoro-2-pyrimidinyl) amino]phenoxy}-N-methyl-2-pyridinecarboxamide
Read More
71145-03-4,1,4-Dihydro-2,6-dimethyl-3-nitro-4-(2-trifluoromethylphenyl)-pyridine-5-carboxylic acid methyl ester
Read More![2-[[3-[[2-(dimethylamino)phenyl]methyl]-2-pyridin-4-yl-1,3-diazinan-1-yl]methyl]-N,N-dimethylaniline 500579-04-4](/data/attachment/201903/23/b396a2326dddb511aae497b01fbd4c77.jpg "2-[[3-[[2-(dimethylamino)phenyl]methyl]-2-pyridin-4-yl-1,3-diazinan-1-yl]methyl]-N,N-dimethylaniline 500579-04-4")
500579-04-4,2-[[3-[[2-(dimethylamino)phenyl]methyl]-2-pyridin-4-yl-1,3-diazinan-1-yl]methyl]-N,N-dimethylaniline
Read More
1443437-74-8,N-(4-chlorophenyl)-1-(3-(furan-2-yl)benzoyl)piperidine-3-carboxamide
Read More
1125-29-7 1,3,5-Trimethyl-1H-pyrazole-4-carboxylic acid
Read More
![[2-(aminocarbonyl)phenyl]acetic acid 23362-56-3](/data/attachment/202211/10/9756043560e11c17cf958f3ed54d541a.png.thumb.jpg "[2-(aminocarbonyl)phenyl]acetic acid 23362-56-3")
23362-56-3 [2-(aminocarbonyl)phenyl]acetic acid
Read More
103788-65-4 2-(5-Methyl-2-phenyl-1,3-oxazol-4-yl)ethan-1-ol
Read More
120503-69-7 2-Amino-6-cyclopropylamino-9H-purine
Read More
Deutsche
Español
français
italiano
português
日本語
한국어
العربية
русский
bahasa Indonesia
Tiếng Việt
Send Email
Skype
3391543003
+86 15195055733
