FRIDAY, Aug. 11, 2017 -- Scientists experimenting with the marijuana compound cannabidiol as an epilepsy treatment must evaluate any interactions with other anti-seizure drugs patients are taking, researchers report.
The new research from the University of Alabama at Birmingham suggests cannabidiol affects blood levels of several anti-seizure drugs, especially clobazam.
Cannabidiol (CBD) has shown promise as a potential anti-seizure compound in animal and human studies, the Alabama researchers said. They are testing it as a therapy for difficult-to-control epilepsy in 39 adults and 42 children.
Other drugs that the participants are taking include clobazam (Onfi), topiramate (Topamax), rufinamide (Banzel), zonisamide (Zonegran), valproate (Depakote) and eslicarbazepine.
Blood levels of some of the drugs changed significantly, but except for clobazam, they did not deviate from the normally accepted range when the patients took cannabidiol, the study found.
The researchers also found that adult patients taking clobazam reported feeling sedated more often.
The study was published Aug. 7 in the journal Epilepsia.
"A perception exists that since CBD is plant-based, that it is natural and safe; and while this may be mostly true, our study shows that CBD, just like other antiepileptic drugs, has interactions with other seizure drugs that patients and providers need to be aware of," study author Dr. Tyler Gaston said in a journal news release.
Another concern was noted with participants taking valproate and CBD. The study found they had higher liver function test results compared with participants not taking valproate.
Monitoring liver function would be important during treatment with CBD, the researchers said.
More information
The U.S. National Institute of Neurological Disorders and Stroke has more on epilepsy.
Posted: August 2017
![(3S)-3-[4-[7-[[(1,1-Dimethylethyl)amino]carbonyl]-2H-indazol-2-yl]phenyl]-1-piperidinecarboxylic acid 1,1-dimethylethyl ester](/data/attachment/201705/26/3446bd2b841689a5afc36447418dc476.png "(3S)-3-[4-[7-[[(1,1-Dimethylethyl)amino]carbonyl]-2H-indazol-2-yl]phenyl]-1-piperidinecarboxylic acid 1,1-dimethylethyl ester")
![N-(1,1-Dimethylethyl)-2-[4-(3S)-3-piperidinylphenyl]-2H-indazole-7-carboxamide](/data/attachment/201705/26/da41ae70b523a458db70333bd1059362.png "N-(1,1-Dimethylethyl)-2-[4-(3S)-3-piperidinylphenyl]-2H-indazole-7-carboxamide")
![2-{4-[(3S)-piperidin-3-yl]phenyl}-2H-indazole-7-carboxamide](/data/attachment/201705/26/d3114dd994f3dda3142cba7d326bcede.jpg "2-{4-[(3S)-piperidin-3-yl]phenyl}-2H-indazole-7-carboxamide")
![9-ethyl-8-iodo-6,6-diMethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile](/data/attachment/201705/28/e48e5d316800efe6192ebfdeec6cf28c.gif "9-ethyl-8-iodo-6,6-diMethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile")
![9-broMo-8-hydroxy-6,6-diMethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile](/data/attachment/201705/28/fe98529212eb834b17a38f13138a35bf.png "9-broMo-8-hydroxy-6,6-diMethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile")
![9-ethyl-6,6-diMethyl-8-(4-Morpholinopiperidin-1-yl)-11-oxo-5a,6,11,11a-tetrahydro-5H-benzo[b]carbazole-3-carbonitrile hydrochloride](/data/attachment/201705/28/36e5363f0c9f92378b75195743e2abb2.jpg "9-ethyl-6,6-diMethyl-8-(4-Morpholinopiperidin-1-yl)-11-oxo-5a,6,11,11a-tetrahydro-5H-benzo[b]carbazole-3-carbonitrile hydrochloride")
![2-Methylpyrazolo[1,5-a]pyrimidine-6-carboxamide](/data/attachment/201706/03/2e19d959128718d26901f9909d7b9342.jpg "2-Methylpyrazolo[1,5-a]pyrimidine-6-carboxamide")
![11-(1-Methylpiperidin-4-ylidene)-6,11-dihydro-5H-benzo[d]iMidazo[1,2-a]azepine](/data/attachment/201706/03/1549d9affee63ead337049001f25d9fa.jpg "11-(1-Methylpiperidin-4-ylidene)-6,11-dihydro-5H-benzo[d]iMidazo[1,2-a]azepine")
![tert-butyl 5-tosyl-5H-pyrrolo[2,3-b]pyrazin-2-ylcarbamate](/data/attachment/201706/03/8a3c0fcdeb9ed744fc854cf248d4d53e.jpg "tert-butyl 5-tosyl-5H-pyrrolo[2,3-b]pyrazin-2-ylcarbamate")
![2-Furanpropanol, 5-[2-[(2S,4R,6R)-6-[[(2S,3S,4R,5R)-5-[(2S)-2,3-bis[[(1,1-dimethylethyl)dimethylsilyl]oxy]propyl]tetrahydro-4-methoxy-3-[(phenylsulfonyl) methyl]-2-furanyl]methyl]tetrahydro-4-methyl-5-methylene-2H-pyran-2-yl]ethyl]tetrahydro-4-methylene-,](/data/attachment/201706/03/3575f40dcc389832ca73cc99972a645b.gif.thumb.jpg "2-Furanpropanol, 5-[2-[(2S,4R,6R)-6-[[(2S,3S,4R,5R)-5-[(2S)-2,3-bis[[(1,1-dimethylethyl)dimethylsilyl]oxy]propyl]tetrahydro-4-methoxy-3-[(phenylsulfonyl) methyl]-2-furanyl]methyl]tetrahydro-4-methyl-5-methylene-2H-pyran-2-yl]ethyl]tetrahydro-4-methylene-,")
![6-[(6-Bromo-1H-[1,2,3]triazolo[4,5-b]pyrazin-1-yl)methyl]-7-fluoroquinoline](/data/attachment/201706/07/27ae4307b53f4294590fb8f914894490.jpg "6-[(6-Bromo-1H-[1,2,3]triazolo[4,5-b]pyrazin-1-yl)methyl]-7-fluoroquinoline")
![7-Trifluoromethyl-imidazo[1,2-a]pyridine](/data/attachment/201706/07/24ba6100528abe0753ad9e82ef8dc810.gif "7-Trifluoromethyl-imidazo[1,2-a]pyridine")
![2-AMino-4,5,6,7-tetrahydro-benzo[b]thiophene-3-carboxylic acid tert-butyl ester](/data/attachment/201706/07/22aadd4c55094254a681014935f56827.jpg "2-AMino-4,5,6,7-tetrahydro-benzo[b]thiophene-3-carboxylic acid tert-butyl ester")
![Benzenemethanol, a-[(1S)-1-aminoethyl]-4-hydroxy-,(aR)](/data/attachment/201706/07/c4adcbada0ef372ae46cbaed643dd18e.jpg "Benzenemethanol, a-[(1S)-1-aminoethyl]-4-hydroxy-,(aR)")
![2(1H)-Quinolinone,5-[(1R)-2-amino-1-[[(1,1-dimethylethyl)dimethylsilyl]oxy]ethyl]-8-hydroxy](/data/attachment/201706/07/e0e9b5769a45af836d70be4140043125.gif.thumb.jpg "2(1H)-Quinolinone,5-[(1R)-2-amino-1-[[(1,1-dimethylethyl)dimethylsilyl]oxy]ethyl]-8-hydroxy")
![2-{[3-(4-Fluorophenyl)-4-oxo-3,4,6,7-tetrahydrothieno[3,2-d]pyrim idin-2-yl]sulfanyl}-N-(6-methyl-1,3-benzothiazol-2-yl)acetamide](/data/attachment/201706/07/5754ee36bdfbf4148f45632422f563b9.jpg "2-{[3-(4-Fluorophenyl)-4-oxo-3,4,6,7-tetrahydrothieno[3,2-d]pyrim idin-2-yl]sulfanyl}-N-(6-methyl-1,3-benzothiazol-2-yl)acetamide")
![2-((3-(2-methoxyphenyl)-4-oxo-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)-N-(6-methylbenzo[d]thiazol-2-yl)acetamide](/data/attachment/201706/08/47a8b3c98aef0b9ba378c4b7c6cef435.jpg "2-((3-(2-methoxyphenyl)-4-oxo-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)-N-(6-methylbenzo[d]thiazol-2-yl)acetamide")
![N-(6-Methyl-2-benzothiazolyl)-2-[(3,4,6,7-tetrahydro-4-oxo-3-phenylthieno[3,2-d]pyrimidin-2-yl)thio]-acetamide](/data/attachment/201706/08/beda6f8f4655aa74d3646cfc7621fb20.jpg "N-(6-Methyl-2-benzothiazolyl)-2-[(3,4,6,7-tetrahydro-4-oxo-3-phenylthieno[3,2-d]pyrimidin-2-yl)thio]-acetamide")
![4(3H)-Quinazolinone,7-bromo-6-chloro-3-[3-(3-hydroxy-2-piperidinyl)-2-oxopropyl]](/data/attachment/201706/09/b600ffca12695094db2c5f6045cb6685.jpg "4(3H)-Quinazolinone,7-bromo-6-chloro-3-[3-(3-hydroxy-2-piperidinyl)-2-oxopropyl]")
![9-OXO-1,2,3,9-TETRAHYDRO-PYRROLO[2,1-B]QUINAZOLINE-6-CARBOXYLIC ACID](/data/attachment/201706/09/d6b395bbfb23e628be7d536d9cc2b512.gif "9-OXO-1,2,3,9-TETRAHYDRO-PYRROLO[2,1-B]QUINAZOLINE-6-CARBOXYLIC ACID")
![2-Butenoic acid, 2-hydroxy-4-[5-(1-Methylethyl)-2,4-bis(phenylMethoxy)phenyl]-4-oxo-, ethyl ester](/data/attachment/201706/09/11c6e17ba89840528c5461ae5350df33.gif "2-Butenoic acid, 2-hydroxy-4-[5-(1-Methylethyl)-2,4-bis(phenylMethoxy)phenyl]-4-oxo-, ethyl ester")
methanone](/data/attachment/201706/09/ca947be16560699c92609cd96b352c02.png.thumb.jpg "[4-amino-2-(ethylsulfanyl)pyrimidin-5-yl](2,3-difluoro-6-methoxyphenyl)methanone")
![Benzenesulfonamide, 2-[(5-bromo-2-chloro-4-pyrimidinyl)amino]-N-methyl](/data/attachment/201706/10/ce0d621896c03bdb67e3b184103e84ff.png.thumb.jpg "Benzenesulfonamide, 2-[(5-bromo-2-chloro-4-pyrimidinyl)amino]-N-methyl")
![1,2,3,4-Tetrahydro-benzo[b]azepin-5-one 1127-74-8](/data/attachment/201901/28/b183df1e648eca4396ad0d319a1254bc.jpg "1,2,3,4-Tetrahydro-benzo[b]azepin-5-one 1127-74-8")
1127-74-8,1,2,3,4-Tetrahydro-benzo[b]azepin-5-one
Read More
4038-14-6,(3,4-dimethoxyphenyl)-phenylmethanone
Read More
![3-Ethynylimidazo[1,2-a]pyridine 943320-53-4](/data/attachment/201901/28/d6294d1dabcee85ee04792b0c0e255c0.jpg "3-Ethynylimidazo[1,2-a]pyridine 943320-53-4")
![2-[3-(trifluoromethyl)phenyl]acetonitrile 2338-76-3](/data/attachment/201901/29/22b99245cb0bbcd2d86f238725d9fb9d.jpg "2-[3-(trifluoromethyl)phenyl]acetonitrile 2338-76-3")
2338-76-3,2-[3-(trifluoromethyl)phenyl]acetonitrile
Read More![2-[3-(trifluoromethyl)phenyl]acetic acid 351-35-9](/data/attachment/201901/29/7dbc74a276a4c124b9460222442fd80f.jpg "2-[3-(trifluoromethyl)phenyl]acetic acid 351-35-9")
351-35-9,2-[3-(trifluoromethyl)phenyl]acetic acid
Read More
2997-92-4,2,2'-Azobis(2-methylpropionamidine) dihydrochloride
Read More
95585-78-7,L-Phenylalanine, 1-methylethyl ester, hydrochloride
Read More
20324-87-2,Disodium 7,7'-(carbonyldiimino)bis(4-hydroxynaphthalene-2-sulphonate)
Read More
182498-32-4,1-(2-bromophenyl)-3-(2-hydroxy-4-nitrophenyl)urea
Read More
![(4-nitrophenyl) 4-[bis(1,3-benzodioxol-5-yl)-hydroxymethyl]piperidine-1-carboxylate 1101854-58-3](/data/attachment/201903/22/9e81dae7e0bdec56ac6052b1872d9626.jpg "(4-nitrophenyl) 4-[bis(1,3-benzodioxol-5-yl)-hydroxymethyl]piperidine-1-carboxylate 1101854-58-3")
1101854-58-3,(4-nitrophenyl) 4-[bis(1,3-benzodioxol-5-yl)-hydroxymethyl]piperidine-1-carboxylate
Read More
170565-89-6,N,N-dimethyl-2-oxo-1,3-dihydroindole-5-sulfonamide
Read More![5,6,11,12-tetrahydrodibenzo[1,2-b:1,2-g][8]annulene 1460-59-9](/data/attachment/201903/23/50930df6d55412ac8f4da0724b497aaf.jpg "5,6,11,12-tetrahydrodibenzo[1,2-b:1,2-g][8]annulene 1460-59-9")
1460-59-9,5,6,11,12-tetrahydrodibenzo[1,2-b:1',2'-g][8]annulene
Read More
![2-chloro-6-[(2R)-2-hydroxy-3-[(2-methyl-1-naphthalen-2-ylpropan-2-yl)amino]propoxy]benzonitrile 284035-33-2](/data/attachment/201903/23/7e63bafe6c4b7e146e00c57dfca99672.jpg "2-chloro-6-[(2R)-2-hydroxy-3-[(2-methyl-1-naphthalen-2-ylpropan-2-yl)amino]propoxy]benzonitrile 284035-33-2")
284035-33-2,2-chloro-6-[(2R)-2-hydroxy-3-[(2-methyl-1-naphthalen-2-ylpropan-2-yl)amino]propoxy]benzonitrile
Read More
![N-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methyl-1-oxo-1,2-dihydroisoquinoline-4-carboxamide 440662-09-9](/data/attachment/201903/23/e26baac537719657acd9f1f55568401d.jpg "N-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methyl-1-oxo-1,2-dihydroisoquinoline-4-carboxamide 440662-09-9")
440662-09-9,N-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methyl-1-oxo-1,2-dihydroisoquinoline-4-carboxamide
Read More![N-[2-[2-(4-chlorophenyl)-1,3-thiazol-4-yl]ethyl]butanamide 932986-18-0](/data/attachment/201903/23/7d2bbd100c8322ae16168937617e1bb2.jpg "N-[2-[2-(4-chlorophenyl)-1,3-thiazol-4-yl]ethyl]butanamide 932986-18-0")
932986-18-0,N-[2-[2-(4-chlorophenyl)-1,3-thiazol-4-yl]ethyl]butanamide
Read More
1234015-52-1,5-(5-(2-(3-aminopropoxy)-6-methoxyphenyl)-1H-pyrazol-3-ylamino)pyrazine-2-carbonitrile
Read More![3-Methyl-3-[(1E)-2-phenylethenyl]-3,2:5,2:5,3-quaterpyridine 1651890-44-6](/data/attachment/201903/23/07bf6fd99e81033df0c83039ccdde036.jpg "3-Methyl-3-[(1E)-2-phenylethenyl]-3,2:5,2:5,3-quaterpyridine 1651890-44-6")
1651890-44-6,3'-Methyl-3''-[(1E)-2-phenylethenyl]-3,2':5',2'':5'',3'''-quaterpyridine
Read More![3-[4-(Dimethylamino)-3-biphenylyl]-1,1-dimethylure 1469924-27-3](/data/attachment/201903/23/f69ad7342d131146640e0c88f73e9a25.jpg "3-[4-(Dimethylamino)-3-biphenylyl]-1,1-dimethylure 1469924-27-3")
1469924-27-3,3-[4'-(Dimethylamino)-3-biphenylyl]-1,1-dimethylure
Read More
3897-94-7,8-Methoxy-N,N-dipropyl-1,2,3,4-tetrahydro-2-naphthalenamine
Read More![4-{4-[(4-{[3-(Acryloylamino)phenyl]amino}-5-fluoro-2-pyrimidinyl) amino]phenoxy}-N-methyl-2-pyridinecarboxamide 1202759-32-7](/data/attachment/201903/23/bb4110673d0676f81860d708092eb660.jpg "4-{4-[(4-{[3-(Acryloylamino)phenyl]amino}-5-fluoro-2-pyrimidinyl) amino]phenoxy}-N-methyl-2-pyridinecarboxamide 1202759-32-7")
1202759-32-7,4-{4-[(4-{[3-(Acryloylamino)phenyl]amino}-5-fluoro-2-pyrimidinyl) amino]phenoxy}-N-methyl-2-pyridinecarboxamide
Read More
71145-03-4,1,4-Dihydro-2,6-dimethyl-3-nitro-4-(2-trifluoromethylphenyl)-pyridine-5-carboxylic acid methyl ester
Read More![2-[[3-[[2-(dimethylamino)phenyl]methyl]-2-pyridin-4-yl-1,3-diazinan-1-yl]methyl]-N,N-dimethylaniline 500579-04-4](/data/attachment/201903/23/b396a2326dddb511aae497b01fbd4c77.jpg "2-[[3-[[2-(dimethylamino)phenyl]methyl]-2-pyridin-4-yl-1,3-diazinan-1-yl]methyl]-N,N-dimethylaniline 500579-04-4")
500579-04-4,2-[[3-[[2-(dimethylamino)phenyl]methyl]-2-pyridin-4-yl-1,3-diazinan-1-yl]methyl]-N,N-dimethylaniline
Read More
1443437-74-8,N-(4-chlorophenyl)-1-(3-(furan-2-yl)benzoyl)piperidine-3-carboxamide
Read More
1125-29-7 1,3,5-Trimethyl-1H-pyrazole-4-carboxylic acid
Read More
![[2-(aminocarbonyl)phenyl]acetic acid 23362-56-3](/data/attachment/202211/10/9756043560e11c17cf958f3ed54d541a.png.thumb.jpg "[2-(aminocarbonyl)phenyl]acetic acid 23362-56-3")
23362-56-3 [2-(aminocarbonyl)phenyl]acetic acid
Read More
103788-65-4 2-(5-Methyl-2-phenyl-1,3-oxazol-4-yl)ethan-1-ol
Read More
120503-69-7 2-Amino-6-cyclopropylamino-9H-purine
Read More
Deutsche
Español
français
italiano
português
日本語
한국어
العربية
русский
bahasa Indonesia
Tiếng Việt
Send Email
Skype
3391543003
+86 15195055733
