Product Name: (S)-2-((Methoxycarbonyl)aMino)-3-Methylbutanoic acid

Synonyms: (S)-2-((Methoxycarbonyl)aMino)-3-Methylbutanoic acid;Methoxycarbonyl valine;(Synonyms:N-(methoxycarbonyl)-L-Valine);N-(Methoxycarbonyl)-L-valine;MOC-L-Valine;L-Valine, N-(Methoxycarbonyl)-;Moc-Val-OH;N-(methoxycarbonyl)-Valine

CAS: 74761-42-5

MF: C7H13NO4

MW: 175.18

EINECS:

Product Categories: Pharmaceuticalintermediates

Mol File: 74761-42-5.mol

(S)-2-((Methoxycarbonyl)aMino)-3-Methylbutanoic acid Structure

(S)-2-((Methoxycarbonyl)aMino)-3-Methylbutanoic acid Chemical Properties

Melting point 109.0 to 113.0 °C

Boiling point 315.9±25.0 °C(Predicted)

density 1.154±0.06 g/cm3(Predicted)

storage temp. Sealed in dry,Room Temperature

pka 4.44±0.10(Predicted)

Safety Information

MSDS Information

(S)-2-((Methoxycarbonyl)aMino)-3-Methylbutanoic acid Usage And Synthesis

Uses (S)-2-((Methoxycarbonyl)aMino)-3-Methylbutanoic acid can be used as Ledipasvir Intermediate, mainly used in laboratory R&D process and chemical production process.

Na2CO3 (1.83 g, 17.2 mmol) was added to an aq solution of NaOH (33 mL of 1 M/H2O, 33 mmol) and L-valine (3.900 g, 33.29 mmol) and the resulting solution was cooled with ice-water bath. Methyl chloroformate (2.8 mL, 36.1 mmol) was added dropwise, the cooling bath was removed and the reaction mixture was stirred at ambient temperature for 3.25 h. The reaction mixture was washed with ether (3x17 mL), and the aqueous phase was cooled with ice-water bath and acidified with conc HCl to a pH of 1-2, and extracted with CH2Cl2 (3x17 mL). The organic phase was dried (anhyd MgSO4), filtered, and concentrated in vacuo. Cap-1 as a white solid (5.00 g, 86%).