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Your Location：Home>Product Center >> Pharmaceutical intermediates >> 163759-49-7 2-O-(2-Methoxyethyl)-5-methyluridine
  • 163759-49-7 2-O-(2-Methoxyethyl)-5-methyluridine
Name:163759-49-7 2-O-(2-Methoxyethyl)-5-methyluridine
CAS No:163759-49-7

PRODUCT DESCRIPTION

2'-O-(2-Methoxyethyl)-5-methyluridine Basic information
Product Name: 2'-O-(2-Methoxyethyl)-5-methyluridine
Synonyms: 2'-O-(2-Methoxyethyl)-5-methyluridine;2'-O-(2-Methoxyethyl)-5-Methyl-uridine, >97%;1-[4-HYDROXY-5-(HYDROXYMETHYL)-3-(2-METHOXYETHOXY)OXOLAN-2-YL]-5-METHYL-3H-PYRIMIDINE-2,4-DIONE;5-Me-2'-O-MOE U;Uridine, 2'-O-(2-Methoxyethyl)-5-Methyl-;5-Me-2'-O-MOE Uridine;2'-O-(2-Methoxyethy)-5-methyluridine;2'-O-MOE-5-Methyluridin
CAS: 163759-49-7
MF: C13H20N2O7
MW: 316.31
EINECS: 500-100-4
Product Categories:
Mol File: 163759-49-7.mol
2'-O-(2-Methoxyethyl)-5-methyluridine Structure
2'-O-(2-Methoxyethyl)-5-methyluridine Chemical Properties
Melting point  115.5-116.5 °C
density  1.41
storage temp.  2-8°C
pka 9.55±0.10(Predicted)
Safety Information
MSDS Information
2'-O-(2-Methoxyethyl)-5-methyluridine Usage And Synthesis
Uses 2'-O-(2-Methoxyethyl)-5-methyluridine is a protected uridine derivative (U829910) and nucleoside used in the preparation of synthetic nucleic acids.    
Chemical Synthesis 1.jpg
2,2'-Anhydro-5-methyluridine (195 g, 0.81 M), tris(2-methoxyethyl)borate (231 g, 0.98 M) and 2-methoxyethanol (1.2 L) were added to a 2 L stainless steel pressure vessel and placed in a pre-heated oil bath at 160°C. After heating for 48 hours at 155-160°C, the vessel was opened and the solution evaporated to dryness and triturated with methanol (200 mL). The residue was suspended in hot acetone (1 L). The insoluble salts were filtered, washed with acetone (150 mL) and the filtrate evaporated. The residue (280 g) was dissolved in CH3CN (600 mL) and evaporated. A silica gel column (3 kg) was packed in CH2Cl2/ acetone/methanol (20:5:3) containing 0.5% Et3NH. The residue was dissolved in CH2Cl2 (250 mL) and adsorbed onto silica (150 g) prior to loading onto the column. The product was eluted with the packing solvent to give product. Yield 160 g, 63%.

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