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  • 1-tert-butyl-3-(4-chlorophenyl)pyrazolo[3,4-d]pyrimidin-4-amine  172889-27-9
Name:1-tert-butyl-3-(4-chlorophenyl)pyrazolo[3,4-d]pyrimidin-4-amine 172889-27-9
CAS No:172889-27-9

PRODUCT DESCRIPTION


Description

PP2 is a substance that has frequently been used in cancer research as a "selective" inhibitor for Src-family kinases. It strongly inhibits the kinases Lck (IC50=4nM), Fyn (5nM) and Hck (5nM), shows weaker inhibition of EGFR (480nM) and practically no inhibition of ZAP-70 (100µM) and JAK2 (50µM). Despite its extensive use as a Src-selective inhibitor, recent research has shown that PP2 is non-selective and inhibits many other kinases with similar affinities.

Basic Info

Chemical Name 1-tert-butyl-3-(4-chlorophenyl)pyrazolo[3,4-d]pyrimidin-4-amine
Synonyms

1qpe;pp2;AG 1879;

CAS No. 172889-27-9
Molecular Formula C15H16ClN5
Molecular Weight 301.77400
PSA 69.62000
LogP 4.06510

Numbering system

MDL number MFCD01568210

Properties

Appearance & Physical State White solid
Density 1.35 g/cm3
Boiling Point 493.5ºC at 760 mmHg
Melting Point 214-216ºC
Flash Point 252.3ºC
Refractive Index 1.676
Vapor Pressure 6.98E-10mmHg at 25°C

Safety Info

HS Code 2933990090

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