Guggulsterone is a plant steroid found in the resin of the guggul plant, Commiphora mukul. Guggulsterone can exist as either of two stereoisomers, E-guggulsterone and Z-guggulsterone. In humans, it acts as an antagonist of the farnesoid X receptor, which was once believed to result in decreased cholesterol synthesis in the liver. Several studies have been published that indicate no overall reduction in total cholesterol occurs using various dosages of guggulsterone, and levels of low-density lipoprotein ("bad cholesterol") increased in many people. Nevertheless, guggulsterone is an ingredient in many nutritional supplements.

Chemical Name	(Z)-Guggulsterone
Synonyms	(17Z)-Pregna-4,17(20)-diene-3,16-dione 4,17(20)-trans-Pregnadiene-3,16-dione;Z-Guggulsterone,(Z)-Pregna-4,17(20)-diene-3,16-dione;
CAS No.	39025-23-5
Molecular Formula	C21H28O2
Molecular Weight	312.44600
PSA	34.14000
LogP	4.64360

MDL number	MFCD01310757

Density	1.1g/cm3
Boiling Point	463.3ºC at 760mmHg
Flash Point	172.3ºC
Refractive Index	1.557
Storage Condition	2-8ºC

Safety Statements	S36
Risk Statements	R37
Hazard Codes	Xi