Welcome to our website!

Product Catalog

Rapid Product Index

Recommended Products

Friend Links

  • Afatinib  850140-72-6
Name:Afatinib 850140-72-6
CAS No:850140-72-6

PRODUCT DESCRIPTION


Description

Afatinib (INN; trade name Gilotrif in the US and Giotrif in Europe, previously Tomtovok and Tovok) is a drug approved in United States, Europe, Taiwan, Mexico, Chile and Japan as well as other countries for the first-line treatment of patients with distinct types of metastatic (EGFR mutation positive) non-small cell lung carcinoma (NSCLC), developed by Boehringer Ingelheim. It acts as an irreversible covalent inhibitor of the receptor tyrosine kinases epidermal growth factor receptor (EGFR) and erbB-2 (HER2).

Basic Info

Chemical Name Afatinib
Synonyms

BIBW 2992;2-Butenamide, N-[4-[(3-chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-, (2E)-;(E)-Afatinib;Tovok;Afatinib freebase;BIBW-2992;trans-Afatinib;(S,E)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide;Collapse

CAS No. 850140-72-6
Molecular Formula C24H25ClFN5O3
Molecular Weight 485.93800
PSA 88.61000
LogP 4.53590

Properties

Appearance & Physical State Off-White Solid
Melting Point 100 - 102 °C

RELATED PRODUCTS