7,8-Dihydroxyflavone (7,8-DHF) is a naturally-occurring flavone found in Godmania aesculifolia, Tridax procumbens, and primula tree leaves. It has been found to act as a potent and selective small-molecule agonist of the TrkB receptor (Kd ≈ 320 nM), the main signaling receptor of brain-derived neurotrophic factor (BDNF). 7,8-DHF is both orally-bioavailable and able to penetrate the blood-brain-barrier.
7,8-DHF has demonstrated remarkable therapeutic efficacy in animal models of a variety of central nervous system disorders, including depression, Alzheimer's disease, cognitive deficits in schizophrenia, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, traumatic brain injury, cerebral ischemia, fragile X syndrome, and Rett syndrome. 7,8-DHF also shows efficacy in animal models of age-associated cognitive impairment and enhances memory consolidation and emotional learning in healthy rodents. In addition, 7,8-DHF possesses powerful antioxidant activity independent of its actions on the TrkB receptor, and protects against glutamate-induced excitotoxicity, 6-hydroxydopamine-induced dopaminergic neurotoxicity, and oxidative stress-induced genotoxicity. It was also found to block methamphetamine-induced dopaminergic neurotoxicity, an effect which, in contrast to the preceding, was found to be TrkB-dependent.

Chemical Name	7,8-DIHYDROXYFLAVONE
Synonyms	7,8-dihydroxy-2-phenylchromen-4-one;7,8-Dihydroxyflavone Hydrate;7,8-Dihydroxy-2-phenyl-4H-chromen-4-one;7,8-Dihydroxyflavone;
CAS No.	38183-03-8
Molecular Formula	C15H10O4
Molecular Weight	254.23700
PSA	70.67000
LogP	2.87120

Density	1.443g/cm3
Boiling Point	494.4ºC at 760 mmHg
Melting Point	243-246ºC
Flash Point	193.5ºC
Refractive Index	1.698

RTECS	DJ3004000
Safety Statements	24/25
HS Code	2914400090
Symbol	GHS07
Hazard Declaration	H302
Signal Word	Warning