Cinacalcet (INN) is a drug that acts as a calcimimetic (i.e. it mimics the action of calcium on tissues) by allosteric activation of the calcium-sensing receptor that is expressed in various human organ tissues (Van Wagenen et al. (2001), U.S. Pat. 6,211,244). It is sold by Amgen under the trade name Sensipar in North America and Australia and as Mimpara in Europe. Cinacalcet is used to treat secondary hyperparathyroidism (elevated parathyroid hormone levels), a consequence of end-stage renal disease. Cinacalcet is also indicated for the treatment of hypercalcemia in patients with parathyroid carcinoma. Cinacalcet was FDA approved in March 2004, and was the first allosteric G protein-coupled receptor modulator to enter the pharmaceutical market. In 2014, cinacalcet was 76th out of the top 100 drugs in the list of largest selling pharmaceutical products.

Chemical Name	cinacalcet
Synonyms	Mimpara;Cinacelcet HCl;AMG 073;Unii-uaz6V7728s;Regpara;Cinacalcet;KRN 1493;Sensipar;Collapse
CAS No.	226256-56-0
Molecular Formula	C22H22F3N
Molecular Weight	357.41200
PSA	12.03000
LogP	6.53290

Appearance & Physical State	yellow oil
Density	1.154 g/cm3
Boiling Point	440.9ºC at 760mmHg
Flash Point	220.5ºC
Refractive Index	1.563
Vapor Pressure	5.67E-08mmHg at 25°C

HS Code	2921499090