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Your Location：Home>Product Center >> Pharmaceutical API >> Imatinib mesylate 220127-57-1
  • Imatinib mesylate 220127-57-1
Name:Imatinib mesylate 220127-57-1
CAS No:220127-57-1

PRODUCT DESCRIPTION

Imatinib mesylate
CAS No.: 220127-57-1
Synonyms:
  • STI-571;
  • GLEEVEC®;
  • GLIVEC;
  • Gleevac;
  • Imatinib methanesulfonate;
  • 4-[(4-Methylpiperazin-1-yl)methyl]-N-(4-methyl-3-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}phenyl)benzamide methanesulfonate;
  • [Imantinib mesylate];
Formula: C30H35N7O4S
Exact Mass: 589.24700
Molecular Weight: 589.70800
PSA: 149.03000
LogP: 5.19690
DescriptionFeedback
A tyrosine kinase inhibitor. Highly specific for BCR-ABL, the enzyme associated with chronic myelogenous leukemia (CML) and certain forms of acute lymphoblastic leukemia (ALL).
PropertiesFeedback
Appearance & Physical State: white crystalline powder .
Density: 0.858 g/mL at 25 °C(lit.)
Boiling Point: 754.9ºC at 760 mmHg
Flash Point: 410.3ºC
Refractive Index: n20/D 1.401(lit.)

Safety InfoFeedback
Symbol:
GHS07
Sign: Warning
hazard declaration: H302
hazard declaration add:
waring notice:
HS Code: 2933990090

 

Imatinib mesylate 220127-57-1 MSDS

SECTION 1: Identification of the substance/mixture and of the company/undertaking
 Product identifiers
    Product name        : Imatinib mesylate    
    REACH No.        : A registration number is not available for this substance as the substance    
    or its uses are exempted from registration, the annual tonnage does not
    require a registration or the registration is envisaged for a later
    registration deadline.
    CAS-No.        : 220127-57-1    
 Relevant identified uses of the substance or mixture and uses advised against
    Identified uses        : Laboratory chemicals, Manufacture of substances    
 
 
SECTION 2: Hazards identification
 Classification of the substance or mixture
 Classification according to Regulation (EC) No 1272/2008
    Acute toxicity, Oral (Category 4), H302
    For the full text of the H-Statements mentioned in this Section, see Section 16.
 Classification according to EU Directives 67/548/EEC or 1999/45/EC
    Xn Harmful        R22    
    For the full text of the R-phrases mentioned in this Section, see Section 16.
 Label elements
 Labelling according Regulation (EC) No 1272/2008
    Pictogram
    Signal word        Warning    
    Hazard statement(s)
    H302        Harmful if swallowed.    
    Precautionary statement(s)        none    
    Supplemental Hazard        none    
    Statements
 Other hazards - none
SECTION 3: Composition/information on ingredients
 Substances
    Synonyms        : Imatinib methanesulfonate; STI-571; CGP 57148; Genfatinib; 4-[(4-    
    methylpiperazin-1-yl)methyl]-N-(4-methyl-3-{[4-(pyridin-3-yl)pyrim
    Formula        : C29H31N7O . CH4O3S    
    Molecular Weight        : 589,71 g/mol    
    CAS-No.        : 220127-57-1    
 Hazardous ingredients according to Regulation (EC) No 1272/2008
    Component        Classification        Concentration    
 Imatinib mesylate
    CAS-No.        220127-57-1        Acute Tox. 4; H302        <= 100 %    
 Hazardous ingredients according to Directive 1999/45/EC
    Component        Classification        Concentration    
 Imatinib mesylate
    CAS-No.        220127-57-1        Xn, R22        <= 100 %    
    For the full text of the H-Statements and R-Phrases mentioned in this Section, see Section 16
SECTION 4: First aid measures
 Description of first aid measures
 General advice
    Consult a physician. Show this safety data sheet to the doctor in attendance.
 If inhaled
    If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.
 In case of skin contact
    Wash off with soap and plenty of water. Consult a physician.
 In case of eye contact
    Flush eyes with water as a precaution.
 If swallowed
    Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.
 Most important symptoms and effects, both acute and delayed
    The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in
    section 11
 Indication of any immediate medical attention and special treatment needed
    no data available
SECTION 5: Firefighting measures
 Extinguishing media
 Suitable extinguishing media
    Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
 Special hazards arising from the substance or mixture
    no data available
 Advice for firefighters
    Wear self contained breathing apparatus for fire fighting if necessary.
 Further information
    no data available
SECTION 6: Accidental release measures
 Personal precautions, protective equipment and emergency procedures
    Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure
    adequate ventilation. Avoid breathing dust.
    For personal protection see section 8.
 Environmental precautions
    Do not let product enter drains.
 Methods and materials for containment and cleaning up
    Pick up and arrange disposal without creating dust. Sweep up and shovel. Keep in suitable, closed
    containers for disposal.
 Reference to other sections
    For disposal see section 13.
SECTION 7: Handling and storage
 Precautions for safe handling
    Avoid contact with skin and eyes. Avoid formation of dust and aerosols.
    Provide appropriate exhaust ventilation at places where dust is formed.
    For precautions see section 2.2.
 Conditions for safe storage, including any incompatibilities
    Store in cool place. Keep container tightly closed in a dry and well-ventilated place.
    Recommended storage temperature: 2 - 8 °C
    Store with desiccant.
 Specific end use(s)
    Apart from the uses mentioned in section 1.2 no other specific uses are stipulated
SECTION 8: Exposure controls/personal protection
 Control parameters
 Components with workplace control parameters
 Exposure controls
 Appropriate engineering controls
    Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and
    at the end of workday.
 Personal protective equipment
 Eye/face protection
    Safety glasses with side-shields conforming to EN166 Use equipment for eye protection tested
    and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).
 Skin protection
    Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique
    (without touching glove's outer surface) to avoid skin contact with this product. Dispose of
    contaminated gloves after use in accordance with applicable laws and good laboratory practices.
    Wash and dry hands.
    The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and
    the standard EN 374 derived from it.
 Body Protection
    Complete suit protecting against chemicals, The type of protective equipment must be selected
    according to the concentration and amount of the dangerous substance at the specific workplace.
 Respiratory protection
    For nuisance exposures use type P95 (US) or type P1 (EU EN 143) particle respirator.For higher
    level protection use type OV/AG/P99 (US) or type ABEK-P2 (EU EN 143) respirator cartridges.
    Use respirators and components tested and approved under appropriate government standards
    such as NIOSH (US) or CEN (EU).
 Control of environmental exposure
    Do not let product enter drains.
SECTION 9: Physical and chemical properties
 Information on basic physical and chemical properties
    a) Appearance        Form: solid    
    b) Odour        no data available    
    c) Odour Threshold        no data available    
    d) pH        no data available    
    e) Melting point/freezing        no data available    
    point
    f) Initial boiling point and no data available
    boiling range
    g) Flash point        no data available    
    h) Evapouration rate        no data available    
    i) Flammability (solid, gas) no data available
    j) Upper/lower        no data available    
    flammability or
    explosive limits
    k) Vapour pressure        no data available    
    l) Vapour density        no data available    
    m) Relative density        no data available    
    n) Water solubility        no data available    
    o) Partition coefficient: n- no data available
    octanol/water
    p) Auto-ignition        no data available    
    temperature
    q) Decomposition        no data available    
    temperature
    r) Viscosity        no data available    
    s) Explosive properties        no data available    
    t) Oxidizing properties        no data available    
 Other safety information
    no data available
SECTION 10: Stability and reactivity
 Reactivity
    no data available
 Chemical stability
    Stable under recommended storage conditions.
 Possibility of hazardous reactions
    no data available
 Conditions to avoid
    no data available
 Incompatible materials
    Strong oxidizing agents
 Hazardous decomposition products
    Other decomposition products - no data available
    In the event of fire: see section 5
SECTION 11: Toxicological information
 Information on toxicological effects
 Acute toxicity
    no data available
 Skin corrosion/irritation
    no data available
 Serious eye damage/eye irritation
    no data available
 Respiratory or skin sensitisation
    no data available
 Germ cell mutagenicity
    no data available
 Carcinogenicity
    IARC:        No component of this product present at levels greater than or equal to 0.1% is identified as    
    probable, possible or confirmed human carcinogen by IARC.
 Reproductive toxicity
    no data available
 Specific target organ toxicity - single exposure
    no data available
 Specific target organ toxicity - repeated exposure
    no data available
 Aspiration hazard
    no data available
 Additional Information
    RTECS: Not available
    To the best of our knowledge, the chemical, physical, and toxicological properties have not been
    thoroughly investigated.
SECTION 12: Ecological information
 Toxicity
    no data available
 Persistence and degradability
    no data available
 Bioaccumulative potential
    no data available
 Mobility in soil
    no data available
 Results of PBT and vPvB assessment
    PBT/vPvB assessment not available as chemical safety assessment not required/not conducted
 Other adverse effects
    no data available
SECTION 13: Disposal considerations
 Waste treatment methods
 Product
    Offer surplus and non-recyclable solutions to a licensed disposal company. Dissolve or mix the material
    with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber.
 Contaminated packaging
    Dispose of as unused product.
SECTION 14: Transport information
 UN number
    ADR/RID: -        IMDG: -        IATA: -    
 UN proper shipping name
    ADR/RID: Not dangerous goods
    IMDG: Not dangerous goods
    IATA:        Not dangerous goods    
 Transport hazard class(es)
    ADR/RID: -        IMDG: -        IATA: -    
 Packaging group
    ADR/RID: -        IMDG: -        IATA: -    
 Environmental hazards
    ADR/RID: no        IMDG Marine pollutant: no        IATA: no    
 Special precautions for user
    no data available
SECTION 15: Regulatory information
    This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006.
 Safety, health and environmental regulations/legislation specific for the substance or mixture
    no data available
 Chemical Safety Assessment
    For this product a chemical safety assessment was not carried out
SECTION 16: Other information
 Full text of H-Statements referred to under sections 2 and 3.
    Acute Tox.        Acute toxicity    
    H302        Harmful if swallowed.    
 Full text of R-phrases referred to under sections 2 and 3
    Xn Harmful
    R22 Harmful if swallowed.
 Further information
    Copyright 2014 Co. LLC. License granted to make unlimited paper copies for internal use
    only.
    The above information is believed to be correct but does not purport to be all inclusive and shall be
    used only as a guide. The information in this document is based on the present state of our knowledge
    and is applicable to the product with regard to appropriate safety precautions. It does not represent any
    guarantee of the properties of the product. Corporation and its Affiliates shall not be held
    liable for any damage resulting from handling or from contact with the above product. See 
     and/or the reverse side of invoice or packing slip for additional terms and conditions of sale.

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